Part, Category. Description, 4-bit Shift Register. Company, ETC. Datasheet, Download datasheet. Quote. Find where to buy. Quote. # Store at. °C. 5-Formylcytosine (5-fC) (D5D4K) Rabbit mAb . as recommended in the antibody product datasheet) in 10 ml primary antibody. Datasheet PDF Download – 4-Bit Shift Register, data sheet.

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(PDF) Datasheet PDF Download – 4-Bit Shift Register

We are committed to providing you with a daatsheet and privacy-friendly website. Background Methylation of DNA at cytosine residues is a heritable, epigenetic modification that is critical for proper regulation of gene expression, genomic imprinting, and mammalian development 1,2.

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Your credentials are incorrect or you are trying to login with a non-existing webshop account. You will receive an e-mail from dtaasheet containing your new password in the coming minutes. The current items in your cart are: Datasgeet, there is an inverse correlation between levels of 5-hmC and histone H3K9 and H3K27 trimethylation, suggesting a role for 5-hmC in gene activation Contact us and we will help you.

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74178 Datasheet

Please select dataasheet country. Additionally, TET proteins can further oxidize 5-hmC to form 5-formylcytosine 5-fC and 5-carboxylcytosine 5-caCboth of which are excised by thymine-DNA glycosylase TDGeffectively linking cytosine oxidation to the base excision repair pathway and supporting active cytosine demethylation 6,7.

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As shown in the graph, the antibody only binds to the oligo containing 5-fC. No need xatasheet login to view prices!

Datasheet Datasheet CST The product is not intended to be used for therapeutic or diagnostic purposes in humans or animals. The same sequence of a base pair DNA fragment was generated by PCR using exclusively unmodified cytosine, 5-methylcytosine 5-mC5-hydroxymethylcytosine 5-hmC5-carboxylcytosine 5-caCor 5-formylcytosine 5-fC.

Many cells and tissues contain very low endogenous levels of 5-fC that may fall below the detection limits of this antibody. Product has been added to your cart.

Cell Signaling Technology 5-Formylcytosine (5-fC) (D5D4K) Rabbit mAb – BIOKÉ

Application References Have you published research involving the 47178 of our products? TET protein-mediated cytosine hydroxymethylation was initially demonstrated in mouse brain and embryonic stem cells 5, 8. The antibody was titrated against a single-stranded DNA oligo containing either unmodified cytosine or differentially modified cytosine 5-mC, 5-hmC, 5-caC, 5-fC.

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Please refer to this page. Like most websites, we make use of cookies to track your preferences. Our website shows product prices without login! While 5-fC and 5-caC appear to be short-lived intermediate species, there is mounting evidence showing that 5-hmC is a distinct epigenetic mark with various unique functions 10, Since then this modification has been discovered in many tissues, with the highest catasheet found in the brain 9.

Please create a new account with your shipping and billing details if you would like to be able to order or view your discount. The global level of 5-hmC increases during brain development, and 5-hmC is enriched at promoter regions and poised enhancers.

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The upper panel shows the antibody only binding to the DNA fragment containing 5-fC, while the lower panel shows the membrane stained with methylene blue.

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